The cornea is a window of transparent tissue at the front of the eyeball. It allows light to pass into the eye and provides focus so that images can be seen. Various diseases or injury can make the cornea either cloudy or out of shape. This prevents the normal passage of light and affects vision.
The cornea has three layers (thin outer and inner layers and a thick middle layer). In some diseases, only the inside layer (endothelium) is affected, causing corneal oedema (swelling) and clouding (see below). Endothelial keratoplasty is a modern technique to replace the inside layer of your cornea with the inside layer from a donor cornea through a relatively small incision (opening).
The majority of transplant recipients have sufficiently good vision to be able to drive legally although many need glasses. It can take up to six months until the full improvement is appreciated. Comfort is improved in some cases.
Rare but serious complications
Corneal transplant rejection
A corneal transplant can be identified and attacked by your immune system. This happens in between 6% and 10% of DSAEK recipients in the first two years after transplantation and can cause graft failure. It can often be reversed if anti-rejection medication is started promptly. Rejection remains a possibility for your lifetime. The rejection risk in DMEK appears to be lower than in DSAEK.
When a graft fails, the cornea becomes cloudy again and vision becomes blurred.
This can usually be controlled by eye drops, but occasionally requires surgery and can damage your sight.
About 10% of endothelial grafts dislocate and need to be repositioned in theatre.
This can be removed surgically.
The operation is usually performed under local anaesthetic and takes about one hour. Through a small incision (opening), your endothelium is removed and an 8.5mm disc of donor endothelium is inserted and pressed in position against the back of your cornea by a bubble of air. You will need to lie flat for one hour after the operation. Usually, only two stitches are used to close the incision.
After the operation
You will usually be examined by the surgical team after your surgery and can generally go home the same day. You will be seen again the next day and within one week to make sure the graft stays in position. You will have about six visits to the outpatient clinic in the first year. We generally recommend that you take two weeks off work – discuss your individual circumstances with your doctor. You will need to use anti-rejection eyedrops for at least six months and in some cases indefinitely. The stitches are usually removed at about three months.
A failed transplant can be replaced in a procedure known as a regraft. However, the risk of subsequent rejection and failure increases each time for second and subsequent regrafts.
Consenting for information sharing
We are required to share your information with the Eye Bank who supply donor corneas, to ensure high quality transplant material.
Corneal transplant rejection
Rejection needs urgent treatment as this can lead to failure of the transplant and loss of vision.
Symptoms of rejection are:
If you experience any of these symptoms, you should immediately call our 24-hour emergency phone line 055 516 1586.Download PDF